95th Canadian Chemistry Conference and Exhibition


Biological / Medicinal Chemistry

Sunday AM

BM1TELUS 111

Nucleic Acid Chemistry in Memory of M. O’Neill

Organizer(s) - A. Macmillan, S. Zimmerly
Chair(s) - A. MacMillan, S. Zimmerly

08:00 B.M. Pinto tribute to Melanie O'Neill

08:20 00013 Modulation of the HDV Ribozyme with Aptamers that Respond to Boolean Logic Gates *$Perreault J.-P., Rouleau S.
08:40 00014 Frameshifting Efficiency is Not Determined by the Mechanical Stability of RNA Pseudoknots Ritchie D.B., Foster D.A.N., $Woodside M.T.
09:00 00015 Structural Variation and Uniformity Among Tetraloop-Receptor Interactions and Related Loop-Helix Interactions in RNA Crystal Structures Wu L., Chai D., Fraser M.E., *Zimmerly S.
09:20 00016 A Phylogenetically Conserved Hairpin Switch Modulates 6S RNA Transcriptional Regulation Panchapakesan S.S.S., Unrau P.
09:40 00017 Working Towards Understanding the Functions of Bacterial Non-coding RNAs: The Hammerhead Ribozyme and MAEB RNA *$Perreault J., Yang X., Zhu K., Weinberg Z., Roth A., Breaker R.R., Ferbeyre G., Chartrand P.
10:00 Coffee Break
10:20 00018 Expanding the Nucleic Acid Chemist's Toolbox: New Fluorescent Cytidine Analogues *$Hudson R.H.E., Chicas K., Suchy M.
10:40 00019 Synthesis and Properties of C- and O-Linked C8-Aryl-2'-Deoxyguanosine Adducts *$Manderville R.A.
11:00 00020 Modified Nucleosides: Applications to RNA Cleaving DNAzymes, Sensing DNAzymes, and Developing New Classes of Bio-inspired Materials *$Perrin D.M., Hipolito C.J., Lam C.H., Hollenstein M., Liu E., Renders M., Wang Y.
11:20 00021 Selection and Characterization of an Efficient L-RNA-cleaving DNAzyme Tram K., *Xia J., $Li Y.
11:40 00022 Effect of Solvent on DNA Hybridization and Melting Studied by DNA-Functionalized Gold Nanoparticles *$Liu J.
12:00 00023 Time-dependent Motor Properties of Nucleic-Acid-based Molecular Spiders Samii L., Curmi P.M.G., Linke H., Zuckermann M.J., *$Forde N.R.
12:20 End of Session

BMGlen 209

Applied Nanomaterials

08:00 Joint with MT and PT - see MT3.

12:20 End of Session

BMTELUS 106

Applied Photochemistry in Health Research (joint with OR6)

08:40 See OR6.

12:20 End of Session

BMGlen 203

Polymeric Nanotechnology: Applications in Biomedical Imaging and Drug Delivery (joint with MS5)

08:00 See MS5.

12:00 End of Session


Sunday PM

BM1TELUS 111

Nucleic Acid Chemistry in Memory of M. O’Neill

Organizer(s) - A. Macmillan, S. Zimmerly
Chair(s) - A. MacMillan, S. Zimmerly

13:40 00219 How Do Some RNA and DNA G-quadruplexes Activate Heme to Enhance Peroxidase and Peroxygenase Activity? Shumayrikh N.
14:00 00220 Unwinding of a Stable G-Quadruplex Structure in Human Telomerase RNA by the Helicase RHAU Booy E.P., Meier M., Okun N., Novakowski S.K., Xiong S., Stetefeld J., *$McKenna S.A.
14:20 00221 Partners in Crime: HflX and the Ribosome - Insights into the Functional Cycle of a Novel Universally Conserved Translational GTPase *$Wieden H.-J., Fischer J.J., Coatham M.L., Eagle Bear S., DeLaurentiis E.I., Brandon H., Shields M.J.
14:40 00222 Conformational Dynamics of Primate Nup50 A-to-I Editing Substrates *Dahabieh M.S., Samanta D., Brodovitch J.-C., $O'Neill M.A.
15:00 00223 Synthesis of Modified Nucleic Acids Resembling Intronic Lariat RNA for Investigating the Mechanism of Action of the Yeast Debranching Enzyme (DBR1) Katolik A., Montemayor E., Hart J., *$Damha M.J.
15:20 00224 Structural and Functional Characterization of a Bacterial Immune System Garside E.L., Gesner E.M., Schellenberg M.J., Mehta G., $MacMillan A.M.
15:40 Coffee Break
16:00 00225 Development of A General Approach for Solid-Phase Synthesis of Oligonucleotides Bearing C8-Aryl Guanine Adducts; Demonstrated by the Modification of the Nar1 Recognition Sequence Sproviero M., Rankin K.M., *$Manderville R.A.
16:20 00226 The Synthesis and Gene Silencing Capabilities of siRNAs Modified with Unnatural Heterocyclic Backbone Linkages Efthymiou T.C., Huynh V., Oentoro J., Peel B., $Desaulniers J.P.
16:40 00227 Role of pri-miRNA Tertiary Structure in miR-17~92 miRNA Biogenesis *Chaulk S.G., Zhizhong X., Glover J.N.M., $Fahlman R.F.
17:00 00228 RNA Tracking in Living Cells with Fluorescence-Activating RNA Aptamers Dolgosheina E., Unrau P.J.
17:20 00229 Intra-Accumbens Injection of a Dopamine Aptamer Abates MK-801-Induced Cognitive Dysfunction in a Model of Schizophrenia McConnell E.M., Madularu D., Walsh R., Holahan M., *$DeRosa M.C.
17:40 End of Session

BMGlen 209

Applied Nanomaterials

13:40 Joint with MT and PT - See MT3.

17:20 End of Session

BMTELUS 106

Applied Photochemistry in Health Research (joint with OR6)

13:40 See OR6.

17:00 End of Session

BMGlen 203

Polymeric Nanotechnology: Applications in Biomedical Imaging and Drug Delivery (joint with MS5)

13:40 See MS5.

16:40 End of Session


Monday AM

BM2TELUS 106

Biophysical Chemistry (joint with PT)

Organizer(s) - M. Khajepoor, E. Prenner
Chair(s) - L. Johnston, E. Kooijman

08:00 00587 Interactions of Biosurfactants with Lipid Membranes Patel H., Nazari M., *Heerklotz H.
08:40 00588 Pulmonary-Surfactant Dysfunction is Cholesterol Dependent *$Amrein M.W., Pratt R.M., Gunasekara L., Todorov N., Lam D.K., Veldhuizen R.A.W.
09:00 00589 Effect of Pollutants on Lung Surfactant Model Membranes Bakr A.., Conway J., Mann A., Schmidt R., DeWolf C.E.
09:20 00590 Microcalorimetry for Membrane and Lipid Characterization *Frasca V.
09:40 00591 The Secret Life of a Phospholipid in Plants: The Physical Chemistry of DGPP *$Kooijman E.E., Rapovy S., Strawn L., Babb A., Testerink C.
10:00 Coffee Break
10:20 00592 Probing Membrane Restructuring with Caged Ceramides Carter Ramirez D.M., Kim Y.A., Costain W.J., Bittman R., *$Johnston L.J.
10:40 00593 Characterizing Sphingolipid Organization in Membranes Thewalt J.
11:00 00594 2H NMR Relaxation and Composition Fluctuations in Membranes Davis J.H., Ziani L., $Schmidt M.
11:20 00595 Influence of the Membrane Composition of Retinal Photoreceptors on the Reversible Binding of a Neuronal Calcium Sensor Protein (NCS), Recoverin: A Solid-State NMR and FTIR Study Valois-Paillard G., Potvin-Fournier K., Calvez P., Salesse C., *$Auger M.
11:40 00596 Apolipoprotein Interaction with Phosphatidylglycerol and Phosphatidylcholine Membranes *$Weers P.M., Chiu M., Prenner E.J.
12:00 00597 Biophysical Studies on Conformational and Functional Properties of the Uncoupling Proteins of the Central Nervous System *$Jelokhani-Niaraki M.
12:20 End of Session

BMGlen 209

Applied Nanomaterials

08:00 Joint with MT and PT - See MT3.

12:20 End of Session

BMTELUS 111

Multiscale Bio/Physical/Chemical Modelling

08:00 See PT3.

12:20 End of Session


Monday PM

BM2TELUS 106

Biophysical Chemistry (joint with PT)

Organizer(s) - M. Khajepoor, E. Prenner
Chair(s) - S. Wetmore, J. Stetefeld

13:40 00776 Surface-Active Proteins on Different Surfaces: Effects of Hydrophobicity and Curvature *$Dutcher J.R., Kurylowicz M., Giuliani M.
14:20 00777 Engineering Cell Surfaces via Liposome Fusion for Spatiotemporal Control of Cell-Cell Assembly Yousaf M.N.
14:40 00778 The Effect of Lithium Ions on the Hydrophobic Effect: Does Lithium Affect Hydrophobicity Differently than Other Ions? *$Khajehpour M.
15:00 00779 Cyclic Polyprolines: How to Bend a Molecular Ruler Scully C.C.G., *Yudin A.K.
15:20 00780 The Effect of Charge on Diffusion in Biofilm Golmohamadi M., *$Wilkinson K. WITHDRAWN
15:40 Coffee Break
16:00 00781 Computer Modeling of the DNA Glycosylases *Wetmore S.D.
16:20 00782 Some Computational Insights Into Oxygen Activation In Non-Heme Iron Enzymes Fortowsky G., Bushnell E.A.C., *$Gauld J.W.
16:40 00783 Biophysical Approaches to Mapping a Protein Interaction Network Necessary for Bacterial Iron Uptake *$Pawelek P.D., Jaworski I., Khalil S.
17:00 00784 Novel Inhibitors of Protein Methyltransferases *$Schapira M., Nguyen K.
17:20 End of Session

BM4Macleod A2,3

Microbial Chemistry of Fossil Fuels (joint with EN)

Organizer(s) - R. Turner, L. Gieg
Chair(s) - L. Gieg, R. Turner

13:40 00788 Hydrocarbons á la Carte: 'Fines' Dining by Oil Sands Tailings Pond Microbes Foght J.M.
14:20 00789 Heavy Metal Attenuation and Mobility in the Wood Creek Sand Channel Aquifer: An Experimental Column Study Kone M., Mayer U., *$Ulrich A.
14:40 00790 Sulfur Biogeochemistry of Syncrude's Mildred Lake Composite Tailings (CT) Deposits *$Warren L.A., Stephenson K., Kendra K., Holland S.P., Colenbrander-Nelson T., Penner T.
15:00 00791 Bioreactors for Oil Sands Tailings Water Treatment *$Liu Y.
15:20 00792 Biodegradation of Oil Sands-related Substrates by Indigenous Tailings Ponds Microorganisms *Gieg L.M., Ramos-Padron E., Clothier L.N., Wilson S.L.
15:40 Coffee Break
16:00 00787 Lipidomic Profiling of Microalgae Cultured with Various Nutrient Levels: Determining Suitability for Biofuel Production *$Melanson J.E., MacDougall K.M., O'Leary S.J.B., McGinn P.J.
16:20 00786 Unravelling the Pathways and Roles of Organisms in Anaerobic Benzene-degrading Cultures Devine C., Luo F., Gitiafroz R., Ho C., Mahadevan R., *$Edwards E., Beiko R.
16:40 00785 Recent Advances in Petroleum Microbiology: Sulfur Cycle Management, Corrosion Control and Improved Production Voordouw G.
17:20 End of Session

BM-PoExhibition Hall CD

Poster Session

From 18:00 until 19:30

BM1 - Nucleic Acid Chemistry posters

18:00 00793 New Fluorescent Cytosine Analogs: Synthesis and Preliminary Evaluation Suchy M., $Hudson R.H.E.
18:00 00794 Push-Pull C-Linked 8-Aryl-Deoxyguanosine Nucleosides for Distinguishing Syn vs. Anti Conformation in the Nar1 Restriction Sequence Rankin K.M., Fadock K.L., *$Manderville R.A.
18:00 00795 Using the Oxidative Chemistry of C8-Furyl-2'-Deoxyguanosine Adducts to Synthesize Site Specific DNA Cross-Links Witham A.A., *Sproviero M., $Manderville R.A.
18:00 00796 Synthesis and Biological Evaluation of RNAs that Contain PNA-RNA Dimer Gong W., $Desaulniers J.P.
18:00 00797 Colorimetric Detection of Analytes Using Aptamer-based Rolling Circle Amplification Wang L., *Tram K., Li J., $Li Y.
18:00 00798 Synthesis and Characterization of Nucleoside Adducts to Probe Recognition and Repair by O6-Alkylguanine DNA Alkyltransferases O'Flaherty D.K., McManus F.P., Noronha A.M., *$Wilds C.J.
18:00 00799 Hydrolytic Stability of O-Linked C8-2'-Deoxyguanosine Adducts Derived from Phenolic Carcinogens Kuska M.S., *$Manderville R.A.
18:00 00800 Comparing tRNA Modification by Archaeal Pseudouridine Synthases Cbf5 and Pus10 Kamalampeta R., $Kothe U.
18:00 00801 A Platinum Phenanthroimidazole Complex as an Input on a Contractile DNA Nanoswitch $Sen D., *Huang Y.C., Sleiman H.F., Castor K.

BM2 - Biophysical Chemistry posters

18:00 00802 Preparation and Performance of NanoMagnetite/MCM41 Catalyst as a Heterogeneous Peroxiadse Model Enzyme *$Fallah F., Mahmoudi A., Nazari K.
18:00 00803 Determining the Kinetics of Membrane Fusion Induced by Small Lipophillic Molecules Nguyen T.T., *$Cramb D.T.
18:00 00804 Conformational Preferences of C8-bound 2'-deoxyguanosine Adducts Sharma P., Manderville R.A., *Wetmore S.D.
18:00 00805 Structures and Relative Energies of heme-Ab complexes: A Computational Study Azimi S., Rauk A.
18:00 00806 Scaffolded Vesicles as a Model Membrane System $Grossutti M., Seenath R., *Lipkowski J.
18:00 00807 Design, Synthesis, Characterization and Application of Peptide-based Artificial Ion Channels Otis F., Biron E., Meillon J.-C., Arseneault M., Racine-Berthiaume C., *Voyer N.
18:00 00808 Taking a Closer Look at the Biosynthesis of NTD in B. subtilis: Analysis of the NtdC-NtdA Coupled Enzyme Reaction by Ion-paired HPLC Vetter N.D., Langill D.M., Boisvert J., van Straaten K.E., Jagdhane R., $Palmer D.R.J.
18:00 00809 Interpreting the Barium Blockades of Potassium Channels with the Multi-Ion Permeation Free Energy Surface Rowley C.N., *$Roux B.
18:00 00810 Atomic Force Microscopy Study of Endoglucanases and Cellobiohydrolases on Native Cellulose Films Quirk A., Wang J., *Lipkowski J., Dutcher J.R., Clarke A.J., Hill C.
18:00 00811 Insights into the Synergistic Effect for the Degradation of Native Cellulose Moula M.G., Quirk A., Hill C., Dutcher J.R., Clarke A.J., *$Lipkowski J.
18:00 00812 Electrochemical Studies of Novel Tethered Model Membranes for the Investigation of Membrane Associated Proteins Seenath R., *Leitch J., $Lipkowski J.
18:00 00813 Peroxidative Nitration of Aromatic Compounds at Mild Conditions Using Peroxidase Enzyme *$Nazari K., Haghighian Z., Rezaie-Rod A., Samimi V.
18:00 00814 DNA Stickers Promote Polymer Adsorption onto Cellulose Sato T., Ali M., $Pelton R., *Cranston E.
18:00 00815 Investigations of a Fluorescence Based Method for Early Detection of Mastitis in Dairy Cows Owen E.M., McInnis J.M., Wagner B.D., *$Whelan W.M.
18:00 00816 TyrA Family Enzymes: Insights into L-Tyrosine Binding Shlaifer I.S., $Turnbull J.T.
18:00 00817 Mass-Tuned Initial Excited-state Structural Dynamics of 5-Deuterouracil from UV Raman Spectroscopy *Teimoory F., Ng S., $Loppnow G.R.
18:00 00818 Characterization of Mono- and Bifunctional Forms of a Tyrosine Biosynthetic Enzyme from Haemophilus influenzae. Kim H.Y., *Quashi P.K., $Turnbull J.
18:00 00819 Binding of Glycopeptide Haptens to a Monoclonal Anti-Shigella flexneri Y Antibody: Insights from Molecular Dynamics Simulations Shi Y., *Pinto B.M.
18:00 00820 PGSTE NMR Measurements of Water Self-diffusion in Supercooled NaCl Aqueous Solutions $Garbacz P., Price W. S.
18:00 00821 In Silico Drug Design to Prevent Oligomerization of Ab in Alzheimer's Disease Petoyan A., *$Rauk A.
18:00 00822 Design of Inhibitors to Resist Ab Oligomerisation and Ab-Cu2+ Binding Opare S.K.A., Petoyan A., *Rauk A.
18:00 00823 Design, Synthesis and Biological Evaluation of Resveratrol Analogues as Anti-Inflammatory and Potential Chemopreventive Agents Aldawsari F., *$Velazquez C.
18:00 00824 Development of a New Method for Fluorogenic Protein Labelling Strmiskova M., Lachance H., Caron K., Goto N.K., *$Keillor J.W.
18:00 00825 Studying the Role of Ribonucleases (RNases) Within Foodborne Pathogen, Listeria monocytogenes Kanda P., Guarne A., $Li Y.
18:00 00826 Coarse-grained and Atomistic Simulations of Lipid Domain Formation Bennett W.F.D., Mendez-Villuendas E., Singh G., Baoukina S., *$Tieleman D.P.
18:00 00827 The Role of Anionic and Cationic Lipid Mixtures in Gene Delivery Process Afshinmanesh E., Baoukina S., Mendez-Villuendas E., $Tieleman D.P.
18:00 00828 Structural and Thermodynamic Studies of the Bacterial Kinase AnmK *Tavassoli M., $Khajehpour M., Mark B.L., Bacik J.-P.
18:00 00829 Dissecting the Mechanism of ETV6 PNT Domain Self-association Huang-Hobbs H., Cetinbas N., Sorensen P.H.B., $McIntosh L.P.
18:00 00830 Theoretical Investigation of the Catalytic Mechanism of Maleate Isomerase Dokaininsh H.M., Ion B.F., *$Gauld J.W.
18:00 00831 Characterization of Nanoparticles for Immunotolerance Induction in Solution and in the Chicken Embryo Chorioallantoic Membrane Durst H.F., $Cramb D.T.
18:00 00832 The Adsorption of a Face-wise Amphipathic a-Helical Peptide onto Hydrophobic Surfaces Naka T.L., Roy S., *$Hore D.K.
18:00 00833 Thermodynamics of Fatty Acid Aggregation Using Computer Simulations Janke J.J., Bennett W.F.D, *$Tieleman D.P.
18:00 00834 In Vivo Activity of a Photo-switchable DNA-binding Protein Kim Y.B., Mazumder M., Brechun K.E., McMillen D., *$Woolley G.A.

BM4 - Microbial Chemistry of Biofuels and Fossil Fuels posters

18:00 00835 A Facile Process for a Biofilm-Inoculation of Bioreactors: Uses in Oilsands Tailings Pond Water Remediation Lemire J., Demeter M.A., George I., Kaufman L., Ceri H., *$Turner R.
18:00 00836 Anaerobic Naphtha Degradation as a Potential Driver for Methanogenesis in Tailings Ponds Wilson S.L., Ramos-Padron E., Voordouw G., $Gieg L.M.
18:00 00837 Biofilm Mediated Aerobic Degradation of Naphthenic Acids Demeter M.A., George I., Lemire J., Ceri H., $Turner R.J.
18:00 00838 Anaerobic Biodegradation of Naphthenic Acids by Tailings Pond Microorganisms *Clothier L.N., $Gieg L.M.

BM5 - Antimicrobial and Host-defense Peptides posters

18:00 00839 Structure-Activity Studies on a Model Antimicrobial Peptide Paquet-Côté P.-A., Provencher M.-E., Cardinal S., Bédard L., Caron E., Lorin A., Noël M., Auger M., *Voyer N.
18:00 00840 Characterization and Antimicrobial Activity of SEA-1 from Streptomyces sp. SPS030 Chaytor J.L., $Vederas J.C.
18:00 00841 Understanding the Biological Activities of Human and Bovine Lactoferricin McDonald L.J., Haney E.F., Arias M., *$Vogel H.J.
18:00 00842 Structural Elements Involved in the Antimicrobial Activity of the Chemokine Thrombicidin-1 *Kwakman P.H.S., Nguyen L.T., Vogel H.J., $Zaat S.A.J.
18:00 00843 Metabolomics as a Novel Approach to Examine the Mechanism of Action of Antimicrobial Peptides *Mickiewicz B., Haney E.F., $Vogel H.J.
18:00 00844 Novel Histone Derived Antimicrobial Peptides preferentially Interact with Bacterial Membrane Lipids in Monolayer Systems Berezowski N.S., Chiu M.H., Vogel H.J., $Prenner E.J.
18:00 00845 Exploring the Antimicrobial Activity of 5-hydroxy-tryptophan Substituted Tritrpticin Peptides Arias M., $Vogel H.J.
18:00 00846 Optimization of a Novel Steroid Alkaloid Antibiotic Efficient Against Persistent Forms of Staphylococcus aureus Chagnon F., Guay I., Mitchell G., Bouarab K., Malouin F., *$Marsault E.
18:00 00847 The Synthesis, Biological Testing, and Structure-Activity Relationship Studies of Novel Analogues of the Lantibiotic Peptide Lactocin S McKinnie S.M.K., Ross A.C., Little M.J., *$Vederas J.C.
18:00 00848 Peptide-Peptide Interaction Among the Class IIb Two-peptide Bacteriocin, Lactococcin G Etayash H., Soliman W., *$Kaur K.
18:00 00849 Derivatization of Pantothenamide Analogues by Enantioselective Reduction with Baker's Yeast Darabi H., *Akinnusi T.O., $Auclair K.
18:00 00850 Synthetic Antimicrobial Peptide Sequences Derived from the Sequence of Lasso Peptide Microcin J25 Soudy R., *Wang L., $Kaur K.
18:00 00851 Pseudomonas aeruginosa Surface Modifications are Required for Surviving Human Neutrophil Killing Halverson T.W., $Lewenza S.
18:00 00852 The Role of Lactoferrin Binding Protein B in Gram-Negative Pathogens Morgenthau A., Beddek A.J., Schryvers A.

BM6 - Macromolecular Crystallography posters

18:00 00853 Engineering b-glucuronidase for use in Antibody-Directed Enzyme Prodrug Therapy Dalrymple S.A., Jagdhane R., Palmer D.R.J., Sanders D.A.R.
18:00 00854 ATP-Citrate Lyase: Study of Phosphohistidine Loop Using X-ray Crystallography *$Komakula A., Fraser M.E., Fraser M.E
18:00 00855 Structural Studies of Viral RNA Polymerase Replication Complexes Rao C., *Kaczowka C., Barrette-Ng I., $Ng K.
18:00 00856 2.0 Å Crystal Structure of Dihydrodipicolinate Synthase from Campylobacter jejuni with Substrate Pyruvate and Inhibitor L-Lysine Conly C.J.T., Skovpen Y., Dalrymple S.A., van Straaten K.E., Palmer D.R.J., *Sanders D.A.R.

BMGlen 209

Applied Nanomaterials

13:40 Joint with MT and PT - See MT3.

17:20 End of Session

BMTELUS 111

Multiscale Bio/Physical/Chemical Modelling

13:40 See PT3.

17:20 End of Session


Tuesday AM

BM2TELUS 106

Biophysical Chemistry (joint with PT)

Organizer(s) - M. Khajepoor, E. Prenner
Chair(s) - B. Mark, M. Khajehpour

08:00 01150 Pre-Steady-State Kinetic Analysis of Pseudouridine Synthases Reveals Slow Catalysis and Details of RNA Binding Keffer-Wilkes L.C., Kamalampeta R., *$Kothe U.
08:20 01151 Learning About Histone Code Recognition, and Generating New Chemical Tools for Histone Code Analysis *$Hof F., Daze K.D., Pinter T., Ma M.C.F., Pineux F., Whiting A.L., Dubicki K.
08:40 01152 Mechanisms of Horseradish Peroxidase and a-Chymotrypsin *$Dunford H.B.
09:00 01153 Irreversible Inhibitors of Lymphoid Tyrosine Phosphatase Ahmed V.F., Barrios A.M.
09:20 01154 Inhibition of Dihydrodipicolinate Synthase by Targeting its Allosteric Site: Toward Development of New Antimicrobials Skovpen Y.V., *Palmer D.R.J.
09:40 01155 Efforts Towards Inhibitiors of Atg4B Nguyen T.G., $Young R.N.
10:00 Coffee Break
10:20 01156 High Resolution Structures of Lipid-Driven Molecular Complexes *$Privé G.G., Ghanei H., Popovic K.
11:00 01157 Oxidative Labeling and Hydrogen/Deuterium Exchange Mass Spectrometry As Complementary Tools for Probing Membrane Protein Structure and Function *$Konermann L., Pan Y.
11:20 01158 Storage and Delivery Function of Coiled-Coil Domains *$Stetefeld J.
11:40 01159 New Insights into the Link Between b-Lactam Antibiotic Resistance and Bacterial Cell Wall Recycling *$Mark B.L., Bacik J.-P., Khajehpour M., Tavassoli M., Vocadlo D.J., Whitworth G.E.
12:00 01160 Probing Sequence-dependent Mechanics of Collagen Shayegan M., Wieczorek A., Rezaei N., Chan C.K.Y., *$Forde N.R.
12:20 End of Session

BMTELUS 104

Bioanalytical Mass Spectrometry (joint with AN4)

08:00 See AN4.

12:20 End of Session

BMMacleod E2

Metal Ions in Biology (joint with IN7)

08:00 See IN7.

12:20 End of Session

BMTELUS 111

Multiscale Bio/Physical/Chemical Modelling

08:00 See PT3.

12:20 End of Session


Tuesday PM

BM2TELUS 106

Biophysical Chemistry (joint with PT)

Organizer(s) - M. Khajepoor, E. Prenner
Chair(s) - P. Pawelek, M. Khajehpour

13:40 01402 Structural Insights into the Unique Phototransduction Cascade of Anabaena Sensory Rhodopsin Wang S., Shi L., Kawamura I., Kim S.Y., Jung K.H., Ladizhansky V., Brown L.S.
14:20 01403 Phenylalanine Ammonia Lyase Activity in Non-aqueous Media *$D'Cunha G.B.
14:40 01404 Structural and Dynamic Insights into the Function and Fidelity of Poliovirus Polymerase Using NMR *$Boehr D.D., Yang X., Welch J.L., Lum D., Liu X.
15:00 01405 Real-Time Monitoring of Tissue Transglutaminase Conformation Using Kinetic Capillary Electrophoresis Clouthier C.M., Mironov G., Okhonin V., Berezovski M.V., $Keillor J.W. WITHDRAWN
15:20 01406 Engineering Motion into a Rigid Protein: Insights into Bacterial Resistance Clouthier C.M., Gobeil S., Park J., Berghuis A., *$Pelletier J.N.
15:40 Break

16:00 01407 Molecular Mechanisms of Enzyme Allostery Studied by NMR and Calorimetry Freiburger L., Zhu S., Auclair K., *$Mittermaier A.
16:40 Coffee Break
17:00 End of Session

BMTELUS 104

Bioanalytical Mass Spectrometry (joint with AN4)

13:40 See AN4.

15:40 End of Session

BMMacleod E2

Metal Ions in Biology (joint with IN7)

13:40 See IN7.

16:40 End of Session

BMTELUS 111

Multiscale Bio/Physical/Chemical Modelling

13:40 See PT3.

16:40 End of Session


Wednesday AM

BM3TELUS 106

Radiopharmaceutical Chemistry (joint with OR)

Organizer(s) - N. Vasdev, F. Wuest, D. Abrams
Chair(s) - F. Wuest, D.M. Perrin; S. Lapi, R.M. Reilly

08:00 01691 PET Imaging with Radiometals: Nonstandard Isotopes become Standard Lapi S.
08:40 01692 Organometallic OBOC Peptide Libraries for use in Molecular Imaging Cruickshank D.R., $Luyt L.G.
09:00 01693 "Click" Chemistry toward Advanced Probes for Molecular Imaging: From PARACEST MRI Contrast Agents to Dual MRI/PET Molecular Probes Suchy M., Milne M., Bartha R., $Hudson R.H.E.
09:20 01694 55Co-Radiolabeled Organometallic Complex is a Potential PET Imaging Agent for Alzheimer's Diagnosis and Research $Fregien S., McGreer P., Ferriera C., Ruth T., *Schaffer P.
09:40 01695 64Cu Labeling of Anti-CA125 Monoclonal Antibody and Single Chain Variable Fragment for Molecular Imaging and Targeting of Ovarian Cancer Sharma S.K., Wang M., *$Wuest F.
10:00 Coffee Break
10:20 01696 68Ga: A generator-produced Radionuclide for Positron Emission Tomography Lodi F.
11:00 01697 Functionalisation of H2dedpa, a Strongly Binding Acyclic Chelator for Gallium Murphy L., Ferreira C.L., Cawthray J.F., Wester D.W., Adam M.J., Orvig C.
11:20 01698 Nitroimidazole-containing Acyclic Chelators for PET Imaging of Hypoxia with 68Ga Ramogida C.F., Boros E., Cawthray J.F., Ferreira C.L., Orvig C., Adam M.J., Wester D. W.
11:40 01699 Development of a Novel 18F Labeled Radiotracer for the Molecular Imaging of Cyclooxygenase-2 by Positron Emission Tomography Tietz O., Wang M., Sharma S.K., Way J., Wuest M., *$Wuest F.
12:00 01700 The Design of Small Molecules for TrkB Positron Emission Tomography Imaging Bernard-Gauthier V., Kostikov A.P., *$Schirrmacher R.
12:20 01701 High-Yielding One-step Radiofluorination of Multiple Ligands for Imaging and Labeling Aryltrifluoroborates at near-NCA Conditions with SAs of ~10Ci/lmol *$Perrin D.M., Li Y., Liu Z., Ting R.T., Schaffer P., Adam M.J., Benard F., Overall C.M., Ruth
BM5TELUS 111

Antimicrobial and Host-defense Peptides (joint with PT)

Organizer(s) - H. Vogel, N. Mookherjee
Chair(s) - H. Vogel, N. Mookherjee

08:00 01702 Interactions of the Antimicrobial Peptide Gramicidin S and Rationally Designed Analogs with Lipid Bilayer Model and Biological Membranes *$McElhaney R.N.
08:40 01703 De Novo Design and Biophysical Investigation of Antimicrobial Peptides from Mammalian Histones Chiu M.H., Mickiewicz B., Vogel H.J., $Prenner E.J.
09:00 01704 Functional Mimicry of Antimicrobial and Host-defense Peptides *$Schweizer F., Findlay B., Dhondikubeer R., Bera S.
09:20 01705 Characterization of Antimicrobial Activity of Paenibacilllus spp. Lohans C.T., Huang Z., van Belkum M.J., Giroud M., Steels E.M., Sit C.S., Zheng J., McMullen L.M., *$Vederas J.C.
09:40 01706 Puroindoline Derived Trp-rich Antimicrobial Peptides: Unravelling a Multifaceted Mechanism of Action Haney E.F., Petersen A.P., Lau C.K., *$Vogel H.J.
10:00 Coffee Break
10:20 01707 New Insights into the Mechanism of Action of Selected Cationic Antimicrobial Peptides and Lipopeptides *$Straus S.K., Desmond R., Bae J.H., Gerelli Y., Fragneto G., Zaccai G., Kumar P.
10:40 01708 Development of Active and Stable Analogues of the Lantibiotic Peptide Lactocin S Ross A.C., McKinnie S.M.K., *$Vederas J.C.
11:00 01709 Design, Antimicrobial Activity and Comparison of Cationic Lipopeptides and Lipopeptoids Findlay B., Schweizer F., Zhanel G.G.
11:20 01710 SAR Study of Methicillin Resistant Staphylococcus Aureus (MRSA) Pyruvate Kinase Inhibitors as a Novel Anti-bacterial Drug Target Jonadass J.P.S., Kumar N.S., Labriere C., *$Young R.N. WITHDRAWN
11:40 01711 Bacterial Biofilm-induced Expression of Antimicrobial Peptide Resistance Mechanisms $Lewenza S.
12:00 End of Session

BMMacleod C

Carbohydrate Chemistry and Glycobiology (joint with OR7)

08:00 See OR7.

12:20 End of Session

BMMacleod A4

Chemistry of Oil Sands Reclamation and Monitoring (joint with EN3)

08:00 See EN3.

12:20 End of Session

BMMacleod E2

Metal Ions in Biology (joint with IN7)

08:00 See IN7.

12:20 End of Session


Wednesday PM

BM3TELUS 106

Radiopharmaceutical Chemistry (joint with OR)

Organizer(s) - N. Vasdev, F. Wuest, D. Abrams
Chair(s) - N. Vasdev, F. Lodi; R. Schirrmacher, D.N. Abrams

13:40 01860 Introduction of P-18F, B-18F, 18F-Al and 18F-Si Chemistry: 18F-Radiochemistry at the Crossroads? Schirrmacher R.
14:20 01861 The In Vivo Evaluation of a Novel 18F-labelled Radiotracer which Undergoes Rapid and Highly Selective Click Reactions Knight J.C., Wuest M., Way J., *$Wuest F.R.
14:40 01862 High Yielding Conversing Arylboronic Esters into F18 Labeled Aryltrifluoborate with High Specific Activity Liu Z., *$Perrin D., Schaffer P., Li Y., Adam M.
15:00 01863 Prodrug Inspired Imaging Agents as a Prognostic Indicator of Cancer Invasion and Metastasis *$Phenix C.P., Chowdhury M., Vigliarolo B., Cunninghame S.
15:20 01864 A Fully Automated Synthesis for the Production of 4-[18F]Fluorobenzylamine using Solid Phase On-cartridge Extraction/Reduction Way J.D., *$Wuest F.
15:40 Coffee Break
16:00 01865 Enhancing the Effectiveness of Auger Electron Radioimmunotherapy Using Metal-chelating Polymers and Dendrimers *$Reilly R.M., Winnik M.A.
16:40 01866 H4octapa, an Acyclic Chelator to Replace DOTA in 111In-Based Theranostic Radiopharmaceuticals Price E.W., *Bailey G.A., Cawthray J.F., Ferreira C.L., Wester D.W., $Orvig C., Adam M.J.
17:00 01867 PET Study of the Bio-distribution of 3nm Water- Soluble Maleimide Au Nanoparticles: 18F Labeled AuNP Cross the Blood Brain Barrier Zhu J., Chin J, Lennox R.B., $Schirrmacher R.
17:20 01868 Benzylamine Derivatives Synthesis, Radiolabeling and Biodistribution Studies Sharma S.K., Joshua A.V., Strelkov A., Abrams D.N., McEwan A.J.B.
17:40 End of Session

BM5TELUS 111

Antimicrobial and Host-defense Peptides (joint with PT)

Organizer(s) - H. Vogel, N. Mookherjee
Chair(s) - R. McElhaney, S. Strauss

13:40 01869 Defining the Molecular Mechanisms of Immune-modulation by Cationic Host Defence Peptides *$Mookherjee N.
14:20 01870 New Concepts in Anti-infective, Anti-biofilm and Anti-inflammatory Treatments *Janot L., $Hancock R.E.W
14:40 01871 Retro Inversed Host Defense Peptides as Antimicrobials and Vaccine Adjuvants *$Napper S., Kindrachuk J.
15:00 01872 The Human Host-defense Proteins Lactoferrin and Lysozyme Form a Complex in Neutrophil Granules Vogel H.J., Ishida H.
15:40 Coffee Break
16:00 01873 Peptides for Targeting Anticancer Drugs Specifically to the Cancer Site *$Kaur K.
16:20 01874 New Matriptase Inhibitors as Potential Anti-influenza Agents *$Marsault E., Colombo E., Désilets A., Duchêne D., Najmanovich R., Richter M., Leduc R., Beaulieu A.
16:40 01875 Characterization of the Non-covalent Interaction Between the Natural Product Thiostrepton and the TIPAS Protein from Streptomyces lividans Myers C.L., *$Honek J.F.
17:00 End of Session

BM6TELUS 105

Macromolecular Crystallography

Organizer(s) - K. Ng, M. Glover
Chair(s) - M. Glover, K. Ng

13:40 01876 Structure and Mechanism of Action of CC0651, a Highly Specific Inhibitor of the E2 Enzyme Cdc34 Ceccarelli D.F., Tang X., Pelletier B., Orlicky S., Xie W., Plantevin V., Neculai D., Chou Y.-C., Ogunjimi A., Al-Hakim A., Varelas X., Koszela J., Wasney G.A., Vedadi M., Dhe-Paganon S., Cox S., Xu S., Lopez-Girona A., Webb D.R., Tyers M., *Sicheri F.
14:20 01877 Disease Mutations in Ryanodine Receptors *$Van Petegem F., Tung C.C., Lobo P.A., Kimlicka L.
14:40 01878 Insights into Heme Degradation by the IsdG-like Family of Enzymes *$Murphy M.E.P., Ukpabi G.N., Takayama S.J., Mauk A.G., Thackray S., Loutet S.A.
15:00 01879 Toward the Understanding of Polysaccharide Co-Polymerases Mode of Action Cygler M., Kalynych S.
15:40 Coffee Break
16:00 01880 Structural Insights on the Master Regulator of Splicing: PRP8 Schellenberg M.J., Wu T., Ritchie D.B., Atta K., *$MacMillan A.M.
16:20 01881 A Human XRCC4-XLF Complex Bridges DNA during DNA Double Strand Break Repair Junop M.
16:40 01882 Recoginition and Repair of Damaged DNA Ends by Polynucleotide Kinase/Phosphatase Glover M.
17:00 End of Session

BMMacleod C

Carbohydrate Chemistry and Glycobiology (joint with OR7)

13:40 See OR7.

17:20 End of Session


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Bold text denotes the presenting author.   If present, * denotes the corresponding author and $ denotes the principal investigator.

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